Depression is a modern-day disease. It affects more than 17 million Americans. Lifestyle factors may also play a role in the disease. People today are more sedentary, less active, sleep and sunlight deficient, isolated and stressed. This can have a significant impact on their well-being, lives, and jobs. Complex relationships exist between cannabis and depression. Some consumers find that cannabis can improve their mood. Cannabis has not been tested in clinical trials for treating depression. Therefore, it is difficult to determine whether cannabis can help or harm those suffering from depression. Research suggests that there is a complex link between cannabis and depression. New research suggests that cannabis may have a role in reducing or exacerbating depression.